In 2005, twenty year-old Joseph Miles went in search of a cure for a disease he was convinced was turning him into a monster. The result was a killing spree that left a string of dismembered and cannibalized bodies from San Francisco to Seattle. Eight years later, after being tried and sentenced to life in prison, Joseph is still searching for a cure. To do so, he must first escape from super maximum security prison where he has been involved in underground death matches sponsored by the prison guards and has been targeted by two of the prison's most dangerous inmates.
Joseph enlists the aid of a lonely female guard with a history of inappropriate behavior with inmates, and a young model named Selene whom Joseph met in art class when he was still a psychology student. She has followed him obsessively over the years and will do anything to help Joseph escape. But could Selene be even more dangerous and twisted than Joseph Miles? Is she really trying to help him find a cure or does she have darker motivations?